4-Methylmorpholine → HCID 178434651, compound

HRID 57252Notes

Reaction equation

HRID 57252 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1.CN1CCOCC1>CO>[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH:27][S:17]([C:15]2[CH:14]=[CH:13][C:11]3[N:12]=[C:8]([C:3]4[C:4]([CH3:7])=[N:5][NH:6][C:2]=4[NH2:1])[S:9][C:10]=3[CH:16]=2)(=[O:19])=[O:18])=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 660364-ChlorobenzylamineHCID 178434647HCID 178434647, compound

Product 1

HCID 178434651HCID 178434651, compoundYield 16.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

the title compound (21 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), 4-chlorobenzylamine (74 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 434.4 (Cl35 M+1, 100%), 436.4 (Cl37 M+1, 40%). Yield=16%.

Sources & evidence

ORD record
ord-4c0fe5e1decd4f07a2c8d6ded931ad2d
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

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