HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)-3-fluorobenzonitrile → Tert-butyl 2-[(4-cyano-2-fluorobenzyl)amino]-2-methylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)-3-fluorobenzonitrile | HCID 2783149 | — |
| Reactant | tert-Butyl 2-methylalaninate | HCID 7019940 | — |
| Product | Tert-butyl 2-[(4-cyano-2-fluorobenzyl)amino]-2-methylpropanoate | HCID 66652709 | — |
Reaction Steps
The title compound was prepared following general procedure 10 starting from tert-butyl 2-amino-2-methylpropanoate and 4-cyano-2-fluoro benzyl bromide. The title compound was isolated as colorless liquid. 1H NMR (DMSO-d6, 400 MHz) δ 7.78-7.75 (d, J=10.0 Hz, 1H), 7.71-7.65 (m, 2H), 3.70-3.68 (d, J=6.9 Hz, 2H), 2.55 (s, 1H), 1.44 (s, 9H), 1.19 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029405B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-080c1eee73904d978f295de8e8df4485 |
| Source note | uspto-grants-2015_05 |