(R*,R*)-N-[5-[1-Hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]ethyl]-2-(phenylmethoxy)phenyl]formamide → (R,R)-Formoterol

Participants

Reaction Steps

4-benzyloxy-3-formylamino-α-[N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)aminomethyl]benzyl alcohol (120 gms, 0.23 M), 10% Pd/C (12 gms) and denatured spirit (0.6 lit) were introduced in an autoclave. The reaction mass was hydrogenated by applying 4 kg hydrogen pressure at 25-30° C. for 3 hrs. The catalyst was removed by filtration and the clear filtrate concentrated under reduced pressure below 40° C. to yield the title compound. (63 gms, 80%).

Provenance & Evidence