Dimethylamine → HCID 178483399, compound

HRID 57284Notes

Reaction equation

HRID 57284 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].NC1NN=C(CCCO)C=1[C:30]1SC2C=CC=C[C:33]=2[N:34]=1.CNC.C1COCC1>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][N:34]([CH3:33])[CH3:30])=[N:13][NH:12][C:11]=1[NH2:19]

Participants

5

Reactant 4

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 178509116HCID 178509116, compoundHCID 178509119HCID 178509119, compound

Product 1

HCID 178483399HCID 178483399, compound

Procedure

The title compound (100 mg) was prepared using 200 mg (0.59 mmol) of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine, which was derived from 3-(5-amino-4-benzothiazol-2-yl-1H-pyrazol-3-yl)-propan-1-ol, and 5 mL of a 2 M solution of dimethylamine in THF (10 mmol). MS (m/z, ES+): 302.1 (M+1, 100%).

Sources & evidence

ORD record
ord-5d7a8f43ec7649df84fcb2a2d2fba51a
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

Loading…