反应详情

温度

80 °C

To a solution of 2-(3-cyanophenyl)acetic acid (1, 6.2 mmol) in methanol (20 ml) was added sulfurous dichloride (5 ml) and 0.1 ml N,N-dimethylformamide. Then the reaction mixture was heated to 80° C. for 2 h. When TLC indicated that the starting material was consumed, the mixture was concentrated to give the residue. The residue was poured into water (20 ml) and was extracted by ethyl acetate (50 m1*2). The organic layer was dried by anhydrous sodium sulfate, filtered, concentrated to give the desired product. LC-MS: m/z (M+H)=176.5

1. customwas consumed
2. concentrationthe mixture was concentrated
3. customto give the residue
4. extractionwas extracted by ethyl acetate (50 m1*2)
5. dry with materialThe organic layer was dried by anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated