反应详情

A solution of 2-(3-amino-5-methyl-1H-pyrazol-4-yl)-benzothiazole-6-carboxylic acid (1.52 g, 5.5 mmol) in 500 mL of anhydrous methanol containing HCl gas was heated to reflux for 5 hrs. The excess methanol was removed by distillation and the solution was neutralized by the addition of a solution of saturated sodium carbonate. The resulting solids were isolated by filtration to yield 500 mg of the title compound as a yellow solid. MS (m/z, ES+): 289.1 (M+1,100%).

1. temperaturewas heated
2. temperatureto reflux for 5 hrs
3. customThe excess methanol was removed by distillation
4. additionthe solution was neutralized by the addition of a solution of saturated sodium carbonate
5. customThe resulting solids were isolated by filtration