Methyl (5-nitropyridin-2-yl)acetate → Methyl 2-(5-aminopyridin-2-yl)acetate

HRID 572930Notes

Reaction equation

HRID 572930 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1

Participants

4

Reactant 1

HCID 51341867Methyl (5-nitropyridin-2-yl)acetate

Product 1

HCID 53659969Methyl 2-(5-aminopyridin-2-yl)acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The solution of methyl 2-(5-nitropyridin-2-yl)acetate (500 mg, 2.5 mmol) and Pd/C (50 mg) in methanol (20 mL) was stirred under H2 at room temperature for 3 h. Then, the reaction mixture was filtered and evaporated under reduced pressure to get desired product for the next step without further purification.

Workup

  1. filtrationThen, the reaction mixture was filtered
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-04132ee18ea14776832296a6aeed03fb
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

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