Methyl (5-nitropyridin-2-yl)acetate → Methyl 2-(5-aminopyridin-2-yl)acetate

Participants

Reaction Steps

The solution of methyl 2-(5-nitropyridin-2-yl)acetate (500 mg, 2.5 mmol) and Pd/C (50 mg) in methanol (20 mL) was stirred under H2 at room temperature for 3 h. Then, the reaction mixture was filtered and evaporated under reduced pressure to get desired product for the next step without further purification.

Provenance & Evidence