HCID 86719116, compound → HCID 86719117, compound

HRID 572938Notes

Reaction equation

HRID 572938 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH:12]=2)[CH:8]=[CH:9][CH:10]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([CH:11]2[CH2:12][CH2:13][N:14]([C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])[CH2:15][CH2:16]2)[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 1

HCID 86719116HCID 86719116, compound

Product 1

HCID 86719117HCID 86719117, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The solution of tert-butyl 4-(3-(2-methoxy-2-oxoethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate (330 mg, 1.0 mmol) and Pd/C (30 mg) in methanol (10 mL) was stirred under H2 at room temperature for 12 h. Then, the reaction mixture was filtered and evaporated under reduced pressure to get desired product for the next step without further purification. LC-MS: m/z (M+H)=334.4

Workup

  1. filtrationThen, the reaction mixture was filtered
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-f42de9b5443a4e2398b9ebad600f495c
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

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