Dimethylamine → HCID 33702229, compound

HRID 572942Notes

Reaction equation

HRID 572942 reaction equation
O=[C:2]([CH2:8][S:9][C:10]#[N:11])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[CH3:12][NH:13][CH3:14]>C1COCC1>[CH3:12][N:13]([CH3:14])[C:10]1[S:9][CH:8]=[C:2]([CH2:3][C:4]([O:6][CH3:7])=[O:5])[N:11]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 86719118HCID 86719118, compound

Product 1

HCID 33702229HCID 33702229, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of methyl 3-oxo-4-thiocyanatobutanoate (350 mg, 2.02 mmol) in THF (4 ml) was added a vessel containing dimethylamine in THF (2M; 1.01 ml, 2.02 mmol), the reaction mixture was stirred at rt for 3 h. LCMS showed that the desired product was detected, the mixture was concentrated to give the residue, the residue was purified by a standard method to give the desired product.

Sources & evidence

ORD record
ord-3b32ee7b702f4d119ec88b7ea9be153c
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

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