Sodium Methoxide → HCID 90150897, compound

HRID 572943Notes

Reaction equation

HRID 572943 reaction equation
Br[C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10]C)=[O:9])[N:6]=1.[CH3:12][O-:13].[Na+:14]>CO>[CH3:12][O:13][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O-:10])=[O:9])[N:6]=1.[Na+:14]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 71721404Methyl (2-bromo-1,3-thiazol-4-yl)acetate

Product 1

HCID 90150897HCID 90150897, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 2-(2-bromothiazol-4-yl)acetate (80 mg, 0.34 mmol), and sodium methanolate (300 mg) in MeOH was stirred at 85° C. overnight. Then the reaction mixture was concentrated to give the desired product. 1H NMR (METHANOL-d4) δ: 4.04 (s, 3H), 3.47 (d, J=1.1 Hz, 2H), 3.37 (s, 1H). LC-MS: m/z (M+H)=174.2

Workup

  1. concentrationThen the reaction mixture was concentrated

Sources & evidence

ORD record
ord-f49b7f16d8f9437b9018a4e3036daec5
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

Loading…