反应详情

Ethyl 2,4-difluorobenzoate (1.14 g), K3PO4 (1.30 g) and 2-methyl-5-indolol (0.90 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The mixture was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and with brine, and dried. The solution was then concentrated. The concentrate was chromatographed on silica gel with 10% ethyl acetate/hexanes.

1. temperatureThe mixture was cooled
2. washThe solution was washed three times with 1M NaOH solution
3. dry with materialwith brine, and dried
4. concentrationThe solution was then concentrated
5. customThe concentrate was chromatographed on silica gel with 10% ethyl acetate/hexanes