Hydrochloric Acid → HCID 67226071, compound

HRID 573065Notes

Reaction equation

HRID 573065 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:22]=[CH:23][C:24]([C:54]([O:56][CH3:57])=[O:55])=[C:25]([CH:53]=3)[O:26][C:27]3[CH:28]=[C:29]4[C:33](=[CH:34][CH:35]=3)[N:32](C(OC(C)(C)C)=O)[CH:31]=[C:30]4[CH2:43][CH2:44][C:45]([N:47]3[CH2:52][CH2:51][O:50][CH2:49][CH2:48]3)=[O:46])[CH2:17][CH2:16]2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][N:15]2[CH2:16][CH2:17][N:18]([C:21]3[CH:22]=[CH:23][C:24]([C:54]([O:56][CH3:57])=[O:55])=[C:25]([O:26][C:27]4[CH:28]=[C:29]5[C:33](=[CH:34][CH:35]=4)[NH:32][CH:31]=[C:30]5[CH2:43][CH2:44][C:45]([N:47]4[CH2:52][CH2:51][O:50][CH2:49][CH2:48]4)=[O:46])[CH:53]=3)[CH2:19][CH2:20]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67227766HCID 67227766, compound

Product 1

HCID 67226071HCID 67226071, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of EXAMPLE 70C (300 mg) in dioxane (2 mL) was treated with concentrated aqueous hydrogen chloride (0.378 mL) and stirred at room temperature overnight. The solution was concentrated and the residue was used for the next step without further purification.

Workup

  1. concentrationThe solution was concentrated
  2. customthe residue was used for the next step without further purification

Sources & evidence

ORD record
ord-d0caf9e778904f6bb6031027651c3ba6
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Reaction notes

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