Hydrochloric Acid → 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

HRID 573138Notes

Reaction equation

HRID 573138 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:20]>CCOCC>[ClH:20].[ClH:20].[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46785855HCID 46785855, compound

Product 1

HCID 441204811-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of EXAMPLE 336A (3.92 g) in ether was added HCl (25 mL, 2M in ether) and the reaction mixture was stirred for 16 hours at room temperature. The solid product was filtered off, dried and used in next step without further purification.

Workup

  1. filtrationThe solid product was filtered off
  2. customdried
  3. customused in next step without further purification

Sources & evidence

ORD record
ord-c98295b97b0b4652be6e774b9282960a
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Reaction notes

Loading…