反应详情

Methyl 2,4-difluorobenzoate (1.53 g), K3PO4 (1.89 g) and 4-hydroxyindole (1.08 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The reaction was cooled and poured into ether. The solution was washed three times with 1M aqueous NaOH solution, and brine, and dried over Na2SO4. The solution was then concentrated, and the crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes.

1. temperatureThe reaction was cooled
2. washThe solution was washed three times with 1M aqueous NaOH solution, and brine
3. dry with materialdried over Na2SO4
4. concentrationThe solution was then concentrated
5. customthe crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes