Trifluoroacetic acid → HCID 67226105, compound

HRID 573147Notes

Reaction equation

HRID 573147 reaction equation
[CH3:1][N:2]([CH3:39])[CH2:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[O:15][C:16]2[CH:17]=[C:18]([N:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]3)[CH:19]=[CH:20][C:21]=2[C:22]([O:24][CH3:25])=[O:23])[NH:8][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:39][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[O:15][C:16]2[CH:17]=[C:18]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[CH:19]=[CH:20][C:21]=2[C:22]([O:24][CH3:25])=[O:23])[NH:8][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131730906HCID 131730906, compound

Product 1

HCID 67226105HCID 67226105, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 339F (484 mg) in dichloromethane (22 mL) was cooled in an ice bath and 2,2,2-trifluoroacetic acid (11 mL) was added. The reaction was stirred for 2 hours, concentrated and the crude product was chromatographed on silica gel with 7N-methanolic ammonia in methylene chloride.

Workup

  1. concentrationconcentrated
  2. customthe crude product was chromatographed on silica gel with 7N-methanolic ammonia in methylene chloride

Sources & evidence

ORD record
ord-a964747a1c864a338ec57b761ab154fc
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Reaction notes

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