反应详情

温度

100 °C

To a solution of EXAMPLE 342D (650 mg) in dimethylsulfoxide (12 mL) was added piperazine (618 mg). The solution was heated at 100° C. for one hour, cooled, added to dichloromethane, extracted with water three times, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under vacuum.

1. temperaturecooled
2. extractionextracted with water three times
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. customthe solvent was removed under vacuum