Trifluoroacetic acid → HCID 178511287, compound

HRID 573172Notes

Reaction equation

HRID 573172 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][NH:9]C(=O)OC(C)(C)C)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>ClCCl>[NH2:9][CH2:8][C@H:5]1[CH2:6][CH2:7][C@H:2]([OH:1])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453650HCID 178453650, compound

Product 1

HCID 178511287HCID 178511287, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl trans-(4-hydroxycyclohexyl)methylcarbamate (1 g) in dichloromethane (10 ml) was treated with trifluoroacetic acid (10 ml) at 0° C. for two hours. The reaction mixture was concentrated and the residue was dried under vacuum to provide the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-83ab14cf46f7459f9f7dcfe2d812f22f
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Reaction notes

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