Indole → 4-cyclopropyl-1H-indole-3-carboxylic acid

HRID 57319Notes

Reaction equation

HRID 57319 reaction equation
Cl[C:2]1[CH:10]=[C:9](Cl)[CH:8]=[C:7]2[C:3]=1[C:4]([C:12]([OH:14])=[O:13])=[CH:5][NH:6]2.N1[C:23]2[C:18](=CC=CC=2)[CH:17]=C1>>[CH:23]1([C:2]2[CH:10]=[CH:9][CH:8]=[C:7]3[C:3]=2[C:4]([C:12]([OH:14])=[O:13])=[CH:5][NH:6]3)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 798IndoleHCID 103428018HCID 103428018, compound

Product 1

HCID 1186445424-cyclopropyl-1H-indole-3-carboxylic acid

Procedure

Compound 4 was converted into the target indole acid using a similar procedure to Example 42.

Sources & evidence

ORD record
ord-637a5aa522d94592841681e7eb4356ef
Source dataset
uspto-grants-2016_09
Patent number
US09434724B2

Reaction notes

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