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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 5732Generated: October 25, 2026

Hydrochloric Acid → N-{1-(p-methoxybenzyl)-2-(4-oxopiperidino)ethyl}-N-methyl-5-isoquinolinesulfonamide

https://huagongshe.com/reaction/5732

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantMethyl iodideHCID 6328—
ReactantPotassium CarbonateHCID 11430—
Reactanttetrahydrofuran N,N-dimethylformamideHCID 21974620—
ReactantN-{2-(4,4-ethylenedioxypiperidino)-1-[p-(5-isoquinolinesulfonyloxy)benzyl]ethyl}-N-methyl-5-isoquinolinesulfonamideHCID 53669357—
ProductN-{1-(p-methoxybenzyl)-2-(4-oxopiperidino)ethyl}-N-methyl-5-isoquinolinesulfonamideHCID 19796293—

Reaction Steps

The amorphous compound obtained in Example 94 was subjected to alkaline hydrolysis, methylation with methyl iodide and potassium carbonate in dimethylformamide/tetrahydrofuran (1:1), and reflux with 3N hydrochloric acid, to obtain N-{1-(p-methoxybenzyl)-2-(4-oxopiperidino)ethyl}-N-methyl-5-isoquinolinesulfonamide in a colorless amorphous form.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05245034
Source datasetuspto-grants-1993_09
ORD IDord-941e293f0a7c46e8b8635a04d61fecdf
Source noteuspto-grants-1993_09