HRID5732

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID6328

Methyl iodide

CH3I

HCID11430

Potassium Carbonate

CK2O3

HCID21974620

未命名化合物

结构：CN(C(Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)CN1CCC2(CC1)OCCO2)S(=O)(=O)c1cccc2cnccc12

HCID53669357

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CC(CN2CCC(=O)CC2)N(C)S(=O)(=O)c2cccc3cnccc23)cc1

HCID19796293

未命名化合物

PROCEDURE

实验过程

The amorphous compound obtained in Example 94 was subjected to alkaline hydrolysis, methylation with methyl iodide and potassium carbonate in dimethylformamide/tetrahydrofuran (1:1), and reflux with 3N hydrochloric acid, to obtain N-{1-(p-methoxybenzyl)-2-(4-oxopiperidino)ethyl}-N-methyl-5-isoquinolinesulfonamide in a colorless amorphous form.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-941e293f0a7c46e8b8635a04d61fecdf
来源数据集: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05245034
来源说明: uspto-grants-1993_09

反应 SMILES

C1COC2(C[CH2:7][N:6]([CH2:9][CH:10]([N:32]([CH3:46])[S:33]([C:36]3[C:37]4[CH:38]=[CH:39][N:40]=[CH:41][C:42]=4[CH:43]=[CH:44][CH:45]=3)(=[O:35])=[O:34])[CH2:11][C:12]3[CH:17]=[CH:16][C:15](OS(C4C5C=CN=CC=5C=CC=4)(=O)=O)=[CH:14][CH:13]=3)[CH2:5][CH2:4]2)O1.CI.[C:51](=[O:54])([O-])[O-].[K+].[K+].Cl.CN(C)[CH:60]=[O:61].O1CCC[CH2:64]1>>[CH3:60][O:61][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][CH:10]([N:32]([CH3:46])[S:33]([C:36]2[C:37]3[CH:42]=[CH:41][N:40]=[CH:39][C:38]=3[CH:43]=[CH:44][CH:45]=2)(=[O:35])=[O:34])[CH2:9][N:6]2[CH2:7][CH2:64][C:51](=[O:54])[CH2:4][CH2:5]2)=[CH:17][CH:16]=1