反应详情

温度

100 °C

To a solution of EXAMPLE 443C (1.6 g) and pyridinium p-toluenesulfonate (1.2 g) in acetone (10 mL) was added water (2 mL) and the mixture was stirred in a Biotage Initiator microwave reactor at 100° C. for 10 minutes. The mixture was diluted with dichloromethane (300 mL) and washed with aqueous NaHCO3, water, brine and dried over Na2SO4, and filtered. Concentration of the filtrate gave the crude product.

1. washwashed with aqueous NaHCO3, water, brine
2. dry with materialdried over Na2SO4
3. filtrationfiltered