HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573241Generated: October 25, 2026
Hydrochloric Acid → HCID 178470098, compound
https://huagongshe.com/reaction/573241
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thiazole-4-carboxylate | HCID 2795532 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 178470098 | HCID 178470098 | — |
Reaction Steps
Under argon and at 0° C., a 2-molar solution of hydrogen chloride in diethyl ether (370 ml) is added dropwise to a solution of tert-butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (25.0 g) in diethyl ether (200 ml). The reaction mixture is stirred at 0° C. and then slowly warmed to room temperature. After stirring overnight, the solvent and excess hydrogen chloride are removed. This gives 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]piperidinium chloride (20.0 g, 98%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09029549B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-f628e9d64e6647bf9241dc0ed66adaf3 |
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| Source note | uspto-grants-2015_05 |
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