Hydrochloric Acid → HCID 178470098, compound

HRID 573241Notes

Reaction equation

HRID 573241 reaction equation
[ClH:1].[CH2:2]([O:4][C:5]([C:7]1[N:8]=[C:9]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[S:10][CH:11]=1)=[O:6])[CH3:3]>C(OCC)C>[Cl-:1].[CH2:2]([O:4][C:5]([C:7]1[N:8]=[C:9]([CH:12]2[CH2:17][CH2:16][NH2+:15][CH2:14][CH2:13]2)[S:10][CH:11]=1)=[O:6])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2795532Ethyl 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thiazole-4-carboxylate

Product 1

HCID 178470098HCID 178470098, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Conditions

Temperature
0 °C

Procedure

Under argon and at 0° C., a 2-molar solution of hydrogen chloride in diethyl ether (370 ml) is added dropwise to a solution of tert-butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (25.0 g) in diethyl ether (200 ml). The reaction mixture is stirred at 0° C. and then slowly warmed to room temperature. After stirring overnight, the solvent and excess hydrogen chloride are removed. This gives 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]piperidinium chloride (20.0 g, 98%)

Workup

  1. temperatureslowly warmed to room temperature
  2. stirringAfter stirring overnight
  3. customthe solvent and excess hydrogen chloride are removed

Sources & evidence

ORD record
ord-f628e9d64e6647bf9241dc0ed66adaf3
Source dataset
uspto-grants-2015_05
Patent number
US09029549B2

Reaction notes

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