3-[5-(Benzyloxy)pyridin-2-yl]-1-ethyl-1H-pyrazolo[4,3-b]pyridine → 6-(1-Ethyl-1H-pyrazolo[4,3-b]pyridin-3-yl)pyridin-3-ol

Participants

Reaction Steps

A mixture of 3-[5-(benzyloxy)pyridin-2-yl]-1-ethyl-1H-pyrazolo[4,3-b]pyridine (224 mg) and 10% Pd—C (50% wet, 78 mg) in MeOH (3 mL) and AcOEt (3 mL) was hydrogenated under balloon pressure at room temperature overnight. The solid was filtrated and washed with MeOH (50 mL×3). The filtrate was concentrated under reduced pressure. The precipitate was collected by filtration and washed with 25% AcOEt in hexane to give the title compound (137 mg).

Provenance & Evidence