反应详情

A mixture of 3-[5-(benzyloxy)pyridin-2-yl]-1-ethyl-1H-pyrazolo[4,3-b]pyridine (224 mg) and 10% Pd—C (50% wet, 78 mg) in MeOH (3 mL) and AcOEt (3 mL) was hydrogenated under balloon pressure at room temperature overnight. The solid was filtrated and washed with MeOH (50 mL×3). The filtrate was concentrated under reduced pressure. The precipitate was collected by filtration and washed with 25% AcOEt in hexane to give the title compound (137 mg).

1. filtrationThe solid was filtrated
2. washwashed with MeOH (50 mL×3)
3. concentrationThe filtrate was concentrated under reduced pressure
4. filtrationThe precipitate was collected by filtration
5. washwashed with 25% AcOEt in hexane