Hydrochloric Acid → HCID 86687338, compound

HRID 573462Notes

Reaction equation

C(OC(=O)NC(C(=O)[NH:14][CH:15]([CH2:32][C:33]1[CH:38]=[C:37]([F:39])[C:36]([F:40])=[CH:35][C:34]=1[F:41])[CH2:16][C:17](=[O:31])[N:18]1[CH2:23][CH2:22][N:21]2[C:24]([C:27]([F:30])([F:29])[F:28])=[N:25][N:26]=[C:20]2[CH2:19]1)CC(C)C)(C)(C)C.[ClH:44]>>[ClH:44].[O:31]=[C:17]([N:18]1[CH2:23][CH2:22][N:21]2[C:24]([C:27]([F:30])([F:29])[F:28])=[N:25][N:26]=[C:20]2[CH2:19]1)[CH2:16][CH:15]([NH-:14])[CH2:32][C:33]1[CH:38]=[C:37]([F:39])[C:36]([F:40])=[CH:35][C:34]=1[F:41]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 53475942HCID 53475942, compound

Product 1

HCID 86687338HCID 86687338, compound

Procedure

Analogously to example 2 the compound, [3-oxo-1-(2,4,5-trifluoro-benzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-propyl]-amide Hydrochloride (Formula 10) is prepared by saltification of the compound of formula 9 (0.52 gm) using hydrochloric acid. (Yield: 0.45 gm, 96%).

Sources & evidence

ORD record: ord-56b87eae323b4b97a368a37cdeb3d2ea
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09029567B2

Reaction notes

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