反应详情

Under the argon atmosphere, dimethyl-(3-phenoxy-2-oxopropyl)-phosphonate (826 mg, 3.20 mmol) and potassium phosphate (679 mg, 3.20 mmol) were added to a THF solution (16 mL) of the compound (634 mg, 1.60 mmol) produced in Example 13, followed by stirring at room temperature for one day. The reaction solution was added to an aqueous saturated ammonium chloride solution, and the aqueous layer was extracted with ethyl acetate twice. The collected organic layers were washed with a saturated saline, and dried with anhydrous sodium sulfate. The solution was concentrated under reduced pressure, and purified with a column apparatus (Hiflash-SI, Size L, hexane→ethyl acetate:hexane=4:6) manufactured by Yamazen Corporation to obtain a titled compound (426 mg) having the following physical property values.

1. extractionthe aqueous layer was extracted with ethyl acetate twice
2. washThe collected organic layers were washed with a saturated saline
3. dry with materialdried with anhydrous sodium sulfate
4. concentrationThe solution was concentrated under reduced pressure
5. custompurified with a column apparatus (Hiflash-SI, Size L, hexane→ethyl acetate:hexane=4:6)