反应详情

温度

200 °C

A mixture of 4-amino-3,6-dimethyl-2-(3-pyridinyl)thieno[2,3-b]pyridine-5-carboxylic acid (98 mg, 0.327 mmol) (Description 33) and diphenyl ether (2 mL) was heated at 200° C. for 2.5 h. After cooling to RT, the mixture was purified by chromatography on silica gel, eluting with a gradient of 0-100% ethyl acetate in cyclohexane then followed by 10% MeOH in DCM, to afford the title compound (45 mg). LCMS (A) m/z: 256 [M+1]+, Rt 0.61 min (acidic).

1. temperatureAfter cooling to RT
2. customthe mixture was purified by chromatography on silica gel
3. washeluting with a gradient of 0-100% ethyl acetate in cyclohexane