Benzenesulfonyl chloride → HCID 68324140, compound

HRID 573613Notes

Reaction equation

HRID 573613 reaction equation
[CH3:1][C:2]1[S:12][C:5]2[N:6]=[C:7]([CH3:11])[CH:8]=[C:9]([NH2:10])[C:4]=2[C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:19]1([S:25](Cl)(=[O:27])=[O:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:1][C:2]1[S:12][C:5]2=[N:6][C:7]([CH3:11])=[CH:8][C:9]([NH:10][S:25]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:27])=[O:26])=[C:4]2[C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 68324016HCID 68324016, compound

Product 1

HCID 68324140HCID 68324140, compoundYield 19.1%

Procedure

Following the general method as outlined in Example 28, starting from 2,6-dimethyl-3-phenylthieno[2,3-b]pyridin-4-amine (97 mg, 0.381 mmol) (Description 10) and benzenesulfonyl chloride (135 mg, 0.763 mmol), the title compound (28.7 mg) was isolated. LCMS (A) m/z: 395 [M+1]+, Rt 0.96 min (basic), Rt 1.39 min (acidic).

Sources & evidence

ORD record
ord-5188d18411cb4a59bd39d3b9c90f6e8e
Source dataset
uspto-grants-2015_05
Patent number
US09029545B2

Reaction notes

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