反应详情

A mixture of N-{2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide (50 mg, 0.095 mmol) (Example 33), phenylboronic acid (13.97 mg, 0.115 mmol), sodium carbonate (20.23 mg, 0.191 mmol) and PdCl2(dppf).DCM (3.90 mg, 4.77 μmol) in DMF (1 mL) and water (250 μl) was heated at 90° C. under nitrogen, for 3.5 h. The reaction mixture was then cooled to RT and concentrated. Purification by chromatography on silica gel, eluting with a gradient of 0-20% ethyl acetate in DCM, afforded the title compound (28 mg). LCMS (A) m/z: 521 [M+1]+, Rt 1.57 min (acidic), Rt 0.98 min (basic).

1. concentrationconcentrated
2. customPurification by chromatography on silica gel
3. washeluting with a gradient of 0-20% ethyl acetate in DCM