Trifluoroacetic acid → HCID 68380587, compound

HRID 573626Notes

Reaction equation

HRID 573626 reaction equation
[CH3:1][N:2]([CH3:22])[C:3]1[CH:4]=[C:5]([C:9]2[C:17]3[C:16]([NH2:18])=[CH:15][C:14]([CH3:19])=[N:13][C:12]=3[S:11][C:10]=2[CH2:20][CH3:21])[CH:6]=[CH:7][CH:8]=1.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=1.[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35]>>[F:37][C:36]([F:39])([F:38])[C:34]([OH:40])=[O:35].[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([S:30]([NH:18][C:16]2[CH:15]=[C:14]([CH3:19])[N:13]=[C:12]3[S:11][C:10]([CH2:20][CH3:21])=[C:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([N:2]([CH3:22])[CH3:1])[CH:4]=4)[C:17]=23)(=[O:32])=[O:31])=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 73984-Chlorobenzenesulfonyl chlorideHCID 68324018HCID 68324018, compound

Product 1

HCID 68380587HCID 68380587, compound

Procedure

Following general method outlined in Example 1, starting from 3-[3-(dimethylamino)phenyl]-2-ethyl-6-methylthieno[2,3-b]pyridin-4-amine (60 mg, 0.193 mmol) (Description 29) and 4-chlorobenzenesulfonyl chloride (81 mg, 0.385 mmol), the title compound (7.1 mg) was isolated as a TFA salt. LCMS (B) m/z: 486 [M+1]+, Rt 3.03 min.

Sources & evidence

ORD record
ord-9fce5169814a4fdcb6abdf8d0b592715
Source dataset
uspto-grants-2015_05
Patent number
US09029545B2

Reaction notes

Loading…