HRID573717

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8028

Tetrahydrofuran

C4H8O

2 次

HCID2779199

4-Iodophenylsulphur pentafluoride

C6H4F5IS

结构：CC(C)c1nc2c(c(I)c1C=O)[C@@H](O[Si](C)(C)C(C)(C)C)CC1(CCC1)C2

HCID86662517

未命名化合物

HCID178418918

未命名化合物

HCID178461733

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1cc(I)c2c(n1)CC1(CC([C@H](O)c3ccc(S(F)(F)(F)(F)F)cc3)C1)C[C@@H]2O[Si](C)(C)C(C)(C)C

HCID86662516

未命名化合物

PROCEDURE

实验过程

Obtained by starting from (S)-5′-(tert-butyldimethylsilyloxy)-4′-iodo-2′-isopropyl-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carbaldehyde and 1-iodo-4-pentafluorosulfanyl-benzene. A 1.3 M solution of isopropylmagnesium chloride-lithium chloride-complex in tetrahydrofurane is used instead of a 2 M solution of isopropylmagnesium chloride in tetrahydrofurane.

WORKUP

后处理

customObtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2de8249dcc7e49b1aa3bc5ae09f298d7
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09029544B2
来源说明: uspto-grants-2015_05

反应 SMILES

[Si:1]([O:8][C@H:9]1[CH2:18][C:17]2([CH2:21][CH2:20][CH2:19]2)[CH2:16][C:15]2[N:14]=[C:13]([CH:22]([CH3:24])[CH3:23])[C:12](C=O)=[C:11]([I:27])[C:10]1=2)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].I[C:29]1[CH:34]=[CH:33][C:32]([S:35]([F:40])([F:39])([F:38])([F:37])[F:36])=[CH:31][CH:30]=1.C([Mg]Cl)(C)C.[Cl-].[Li+].C([Mg]Cl)(C)C.[O:53]1CCC[CH2:54]1>>[Si:1]([O:8][C@H:9]1[CH2:18][C:17]2([CH2:21][CH:20]([C@@H:54]([C:29]3[CH:34]=[CH:33][C:32]([S:35]([F:40])([F:39])([F:38])([F:37])[F:36])=[CH:31][CH:30]=3)[OH:53])[CH2:19]2)[CH2:16][C:15]2[N:14]=[C:13]([CH:22]([CH3:23])[CH3:24])[CH:12]=[C:11]([I:27])[C:10]1=2)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2]