HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenylphosphine → HCID 90415270, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenylphosphine | HCID 70017 | — |
| Reactant | 2-(1-Azidoethyl)-5-(4-chlorophenyl)-4-methyloxazole | HCID 90415121 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 90415270 | HCID 90415270 | — |
Reaction Steps
SiliaBond® Diphenylphosphine (1500 mg, 1.19 mmol/g) was added to a solution of 2-(1-azidoethyl)-5-(4-chlorophenyl)-4-methyloxazole (366 mg, 1.393 mmol) in anhydrous methanol (15 ml) and shaken for 3 hours. The reaction was filtered and concentrated in vacuo. Flash column chromatography (silica, 40 g) eluting with 2-10% MeOH/DCM afforded 160 mg (white solid). HRMS(B) tR=1.73 min; MS m/z 236.0716
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434719B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-03856303fa484d6eb768a8b464c01e01 |
| Source note | uspto-grants-2016_09 |