反应详情

SiliaBond® Diphenylphosphine (1500 mg, 1.19 mmol/g) was added to a solution of 2-(1-azidoethyl)-5-(4-chlorophenyl)-4-methyloxazole (366 mg, 1.393 mmol) in anhydrous methanol (15 ml) and shaken for 3 hours. The reaction was filtered and concentrated in vacuo. Flash column chromatography (silica, 40 g) eluting with 2-10% MeOH/DCM afforded 160 mg (white solid). HRMS(B) tR=1.73 min; MS m/z 236.0716

1. filtrationThe reaction was filtered
2. concentrationconcentrated in vacuo
3. washFlash column chromatography (silica, 40 g) eluting with 2-10% MeOH/DCM
4. customafforded 160 mg (white solid)