1-(2-Isopropyl-5-methylphenyl)thiourea → (1Z)-1-[3-(5-methyl-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[3-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]butan-2-yl]urea

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Isopropyl-5-methylphenyl)thiourea	HCID 89373168	—
Reactant	2-methyl-3-(4-(1-(4-(trifluoromethoxy) phenyl)-1H-1,2,4-triazol-3-yl)phenyl)butanoyl azide 3-(4-(3-isocyanatobutan-2-yl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole	HCID 90406195	—
Product	(1Z)-1-[3-(5-methyl-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[3-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]butan-2-yl]urea	HCID 90404241	—

Reaction Steps

The title compound was prepared as described in Example 35 using 1-(2-isopropyl-5-methylphenyl)thiourea and 2-methyl-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)butanoyl azide/3-(4-(3-isocyanatobutan-2-yl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole (C35a) and isolated as an off-white powder (0.146 g, 39%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09029560B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-59c1829f9dd34c3ba4e6af68e031de5c
Source note	uspto-grants-2015_05