2,6-Dichloropyrazine → HCID 89400340, compound

Participants

Reaction Conditions

Reaction Steps

N,N′-Diisopropylethylamine (2.50 mL, 14.35 mmol) was added dropwise to a solution of 2,6-dichloropyrazine (525 mg, 3.52 mmol) and (S)-1-(5-fluoropyridin-2-yl)ethanamine hydrochloride (prepared as described in WO2006/123113, 750 mg, 3.52 mmol) in 1-methylpyrrolidin-2-one (4 mL) and the resulting mixture was stirred and heated for 6 hours at 180° C. in a microwave oven. After cooling to ambient temperature, the solvent was evaporated under reduced pressure and the residue was purified by flash chromatography (7:3 hexanes/ethyl acetate) to give the title compound (520 g, 57%) as a brown oil.

Provenance & Evidence