反应详情

A solution of 7 (550 mg) in 3 mL of 80% aqueous acetic acid was heated at 75° C. for overnight. Then the solution was evaporated and the residue obtained was refluxed with 20% NaOH/EtOH (1:1, v/v, 3 mL) for 2 h. The solvent was removed, 10 mL of ice cooled water was added to the residue and the aqueous solution acidified with 1N HCl, extracted with CH2Cl2 (60 mL) and dried over anhydrous Na2SO4. Evaporation of the solvent gave yellow solid Yield: 485 mg (quantitative).

1. customThen the solution was evaporated
2. customthe residue obtained
3. customThe solvent was removed
4. temperature10 mL of ice cooled water
5. additionwas added to the residue
6. extractionextracted with CH2Cl2 (60 mL)
7. dry with materialdried over anhydrous Na2SO4
8. customEvaporation of the solvent