Acetic Acid → HCID 52933493, compound

Participants

Reaction Steps

A solution of 7 (550 mg) in 3 mL of 80% aqueous acetic acid was heated at 75° C. for overnight. Then the solution was evaporated and the residue obtained was refluxed with 20% NaOH/EtOH (1:1, v/v, 3 mL) for 2 h. The solvent was removed, 10 mL of ice cooled water was added to the residue and the aqueous solution acidified with 1N HCl, extracted with CH2Cl2 (60 mL) and dried over anhydrous Na2SO4. Evaporation of the solvent gave yellow solid Yield: 485 mg (quantitative).

Provenance & Evidence