HRID574157

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O

HCID58012119

未命名化合物

结构：CC(C)(NC(=O)C(N)c1ccccc1C(F)(F)F)C(N)=O.Cl

HCID89780485

未命名化合物

PRODUCTS

生成物

结构：CC(C)(NC(=O)C(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O)c1ccccc1C(F)(F)F)C(N)=O

HCID56932663

未命名化合物

PROCEDURE

实验过程

Analogously to Example 1, 25 mg (69 μmol) of [3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid (for the preparation, see WO 2007/134862, Example 156A) and 28 mg (76 mol) of the compound of Example 62A were employed. Purification by HPLC [Method 7] gave 28 mg (63% of theory) of the title compound.

WORKUP

后处理

customPurification by HPLC [Method 7]

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-df3915f380e04ac4938659f99deecf2a
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09034855B2
来源说明: uspto-grants-2015_05

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])[C:11](=[O:21])[N:10]([CH2:22][C:23](O)=[O:24])[N:9]=2)=[CH:4][CH:3]=1.Cl.[NH2:27][CH:28]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[C:44]([F:47])([F:46])[F:45])[C:29]([NH:31][C:32]([CH3:37])([C:34]([NH2:36])=[O:35])[CH3:33])=[O:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])[C:11](=[O:21])[N:10]([CH2:22][C:23]([NH:27][CH:28]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=3[C:44]([F:45])([F:46])[F:47])[C:29]([NH:31][C:32]([CH3:37])([C:34]([NH2:36])=[O:35])[CH3:33])=[O:30])=[O:24])[N:9]=2)=[CH:6][CH:7]=1