[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetic acid → N2-{({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-amino) [2-(trifluoromethyl)phenyl]acetyl}-2-methylalaninamide

Participants

Role	Name	HCID	Charge
Reactant	[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetic acid	HCID 58012119	—
Reactant	N2-{Amino[2-(trifluoromethyl)phenyl]acetyl}-2-methylalaninamide hydrochloride	HCID 89780485	—
Product	N2-{({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-amino) [2-(trifluoromethyl)phenyl]acetyl}-2-methylalaninamide	HCID 56932663	—

Reaction Steps

Analogously to Example 1, 25 mg (69 μmol) of [3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid (for the preparation, see WO 2007/134862, Example 156A) and 28 mg (76 mol) of the compound of Example 62A were employed. Purification by HPLC [Method 7] gave 28 mg (63% of theory) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09034855B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-df3915f380e04ac4938659f99deecf2a
Source note	uspto-grants-2015_05