HCID 6417976, compound → HCID 6417966, compound

HRID 574187Notes

Reaction equation

HRID 574187 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]3[N:19]=[N:18][C:17](Cl)=[CH:16][CH:15]=3)[N:9]=2)=[CH:6][CH:7]=1>C(O)C.[Pd]>[N:18]1[CH:17]=[CH:16][CH:15]=[C:14]([C:10]2[CH:11]=[CH:12][CH:13]=[C:8]([C:5]3[N:4]=[N:3][CH:2]=[CH:7][CH:6]=3)[N:9]=2)[N:19]=1

Participants

4

Reactant 1

HCID 6417976HCID 6417976, compound

Product 1

HCID 6417966HCID 6417966, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

500 mg (1.65 mmol) of 2,6-bis(3-chloropyridazin-6-yl)-pyridine 32 and 17.5 mg (0.08 mmol) of palladium-on-charcoal are dissolved in 50 ml of ethanol. The mixture is stirred at ambient temperature under a hydrogen pressure for 24 hours. The solution is filtered, evaporated under reduced pressure, and then chromatographed on silica gel (eluent: ethyl acetate/petroleum ether: 8/2). The 2,6-bis(3′-pyridazinyl)pyridine 37 is isolated with a yield of 89%.

Workup

  1. filtrationThe solution is filtered
  2. customevaporated under reduced pressure
  3. customchromatographed on silica gel (eluent: ethyl acetate/petroleum ether: 8/2)

Sources & evidence

ORD record
ord-7f87c06275de400e9d6ac867e193917f
Source dataset
uspto-grants-2015_05
Patent number
US09034873B2

Reaction notes

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