反应详情

温度

150 °C

400 mg (2.42 mmol) of pyridazine 44, 177 mg (1.60 mmol) of selenium dioxide and 7 ml of o-dichlorobenzene are introduced into a 100 ml round-bottomed flask equipped with a condenser. The mixture is heated at 150° C. for 4 hours, and then cooled to ambient temperature. An excess of water is added to the precipitate formed, which is filtered off and washed with water. The solid obtained is dried, so as to give the acid 45 with a yield of 74%.

1. customequipped with a condenser
2. temperaturecooled to ambient temperature
3. customformed
4. filtrationwhich is filtered off
5. washwashed with water
6. customThe solid obtained
7. customis dried