反应详情

To a stirring solution of the tert-butyl 2-(5-(2-(benzyloxy)-1,1,1-trifluoropropan-2-yl)-1,3,4-oxadiazol-2-yl)-6-methoxy-5-(trifluoromethyl)pyridin-3-ylcarbamate (707 mg, 1.257 mmol) in DCM (10 ml) was added TFA (3 ml) and stirring continued for 45 min. The resulting mixture was washed with 2M NaOH and the organic phase separated using a phase separator. The solvent was removed in vacuo to afford the title product as a TFA salt; LC-MS Rt=1.42 min [M+H]+ 463.2 Method High pH_v003.

1. washThe resulting mixture was washed with 2M NaOH
2. customthe organic phase separated
3. customThe solvent was removed in vacuo