2-Hydroxyisobutyric acid → 2-(5-(3-Amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)propan-2-ol

HRID 574214Notes

Reaction equation

HRID 574214 reaction equation
[NH2:1][C:2]1[C:3]([C:13]([NH:15][NH2:16])=[O:14])=[N:4][C:5]([Br:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[OH:17][C:18]([CH3:23])([CH3:22])[C:19](O)=O>>[NH2:1][C:2]1[C:3]([C:13]2[O:14][C:19]([C:18]([OH:17])([CH3:23])[CH3:22])=[N:16][N:15]=2)=[N:4][C:5]([Br:12])=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

3

Reactant 2

HCID 116712-Hydroxyisobutyric acidHCID 867295953-Amino-6-bromo-5-(trifluoromethyl)picolinohydrazide2×

Product 1

HCID 715157552-(5-(3-Amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)propan-2-ol

Procedure

The title compound was prepared from 3-amino-6-bromo-5-(trifluoromethyl)picolinohydrazide (Intermediate H) and 2-hydroxy-2-methylpropanoic acid analogously to Example 10 (leave out step 4);

Workup

  1. customleave out step 4)

Sources & evidence

ORD record
ord-bdf73d660b6d4e42a6e45c47867e973f
Source dataset
uspto-grants-2015_05
Patent number
US09034879B2

Reaction notes

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