反应详情

温度

85 °C

A suspension of 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A4) (1.00 g, 3.34 mmol) in dry MeOH (20 ml) was stirred at reflux (85° C.) for 30 min and then treated with hydrazine monohydrate (324 ul, 6.69 mmol). The mixture was returned to heat at reflux for 5 h 30 min and allowed to cool to RT. Water was added and the resulting precipitate was collected by filtration and dried in a vacuum oven to afford the title compound as a biege solid;

1. temperatureto heat
2. temperatureat reflux for 5 h 30 min
3. temperatureto cool to RT
4. filtrationthe resulting precipitate was collected by filtration
5. customdried in a vacuum oven