Trifluoroacetic acid → Trifluoroacetic acid

HRID 574275Notes

Reaction equation

HRID 574275 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12][CH:13]2[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12][CH:13]2[CH2:14][NH:15][CH2:16]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70145969HCID 70145969, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 66185179HCID 66185179, compound

Procedure

To tert-butyl 3-(3-methoxy-4-nitrophenylamino)azetidine-1-carboxylate (9 g) was added TFA (18 mL) at room temperature. The reaction mixture was stirred for 15 min at room temperature and then was concentrated under reduced pressure at 40° C. to give the title compound as TFA salt (7.24 g).

Workup

  1. concentrationwas concentrated under reduced pressure at 40° C.

Sources & evidence

ORD record
ord-1d89ddedab7e46af8702a1ce0e401c0f
Source dataset
uspto-grants-2015_05
Patent number
US09034885B2

Reaction notes

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