HCID 67503378, compound → HCID 67504275, compound

HRID 574298Notes

Reaction equation

HRID 574298 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15](=[O:32])[N:16]([CH:20]2[CH2:29][CH2:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][C:26]=3[O:30][CH3:31])[CH2:21]2)[CH2:17][CH2:18][CH3:19])[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)(C(F)(F)F)=O>[CH3:31][O:30][C:26]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:27]=1[CH2:28][CH2:29][CH:20]([N:16]([CH2:17][CH2:18][CH3:19])[C:15](=[O:32])[CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH2:21]2

Participants

3

Reactant 1

HCID 67503378HCID 67503378, compound

Product 1

HCID 67504275HCID 67504275, compoundYield 93.9%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

This compound was prepared from 36b (6.6 g, 14.8 mmol), and TFA (40 ml) by following Procedure D to give 37b (4.8 g, 92%). 1H NMR (400 MHz, CDCl3) 0.92-0.964 (t, 3H, J=7.6 Hz), 1.63 (m, 3H), 1.84-1.97 (m, 3H), 2.55 (m, 1H), 2.80-2.87 (m, 5H), 2.97-3.34 (m, 9H), 3.82 (s, 3H), 6.64-6.71 (m, 2H), 7.06-7.15 (m, 1H).

Sources & evidence

ORD record
ord-dcaa5b8d9b3343a68948dc0d578fbcb7
Source dataset
uspto-grants-2015_05
Patent number
US09034877B2

Reaction notes

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