反应详情

2-Isothiocyanato-benzoic acid methyl ester (0.58 mL, 3.69 mmol) was added to a solution of 2-isopropyl aniline (500 mg, 3.69 mmol) and sodium methoxide (10 mg) in 2-propanol (10 mL) at room temperature and heated at reflux for 16 hr. The reaction mixture was concentrated to dryness under vacuum. The crude material was washed with dichloromethane (2×10 mL), 10% methanol in chloroform (2×10 mL) and dried under reduced pressure to afford 3-(2-isopropyl-phenyl)-2-mercapto-3H-quinazolin-4-one (600 mg, 55%) as white solid.

1. temperatureheated
2. temperatureat reflux for 16 hr
3. concentrationThe reaction mixture was concentrated to dryness under vacuum
4. washThe crude material was washed with dichloromethane (2×10 mL), 10% methanol in chloroform (2×10 mL)
5. customdried under reduced pressure