反应详情

To methyl 2-(2-bromo-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate (180 mg, 0.600 mmol) was added POCl3 (1 mL, 10.73 mmol). The reaction mixture was heated at reflux for 1 h. After cooling, the reaction mixture was added drop-wise to ice-water. A brown solid precipitated. The solid was filtered and washed with water to give the title compound (158 mg, 83%). 1H NMR (500 MHz, DMSO-d6) δ 2.56 (3H, s), 3.69 (3H, s), 4.01 (2H, s), 6.99 (1H, s).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 1 h
3. temperatureAfter cooling
4. customA brown solid precipitated
5. filtrationThe solid was filtered
6. washwashed with water